Anti-DLG1 antibody (70-120 aa) (STJ192925)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein at the amino acid range 70-120
General Information
| Short Description | Rabbit polyclonal anti-Disks large homolog 1 (70-120 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DLG1 |
| Gene ID | 1739 |
| Uniprot ID | DLG1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein at the amino acid range 70-120 |
| Immunogen Region | 70-120 aa |
| Specificity | DLG1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A. Ubiquitinated.by MARCHF2 which results in its degradation. |
| Function | Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion. May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane. |
| Protein Name | Disks Large Homolog 1Synapse-Associated Protein 97Sap-97Sap97Hdlg |
| Database Links | Reactome: R-HSA-399719Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-447038Reactome: R-HSA-451308Reactome: R-HSA-5673001Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembranePostsynaptic DensitySynapseSarcolemmaApical Cell MembraneCell JunctionCytoplasmColocalizes With Epb41 At Regions Of Intercellular ContactsBasolateral In Epithelial CellsMay Also Associate With Endoplasmic Reticulum MembranesMainly Found In Neurons SomaModerately Found At Postsynaptic Densities |
| Alternative Antibody Names | Anti-Disks Large Homolog 1 antibodyAnti-Synapse-Associated Protein 97 antibodyAnti-Sap-97 antibodyAnti-Sap97 antibodyAnti-Hdlg antibodyAnti-DLG1 antibody |
Information sourced from Uniprot.org