| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Rho GTPase-activating protein 7 (61-110 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DLC1 |
| Gene ID: |
10395 |
| Uniprot ID: |
RHG07_HUMAN |
| Immunogen Region: |
61-110 aa |
| Specificity: |
DLC-1 Polyclonal Antibody detects endogenous levels of DLC-1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human RHG07 at the amino acid range 61-110 |
| Function | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration.in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85. The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation. |
| Protein Name | Rho Gtpase-Activating Protein 7Deleted In Liver Cancer 1 ProteinDlc-1Hp ProteinRho-Type Gtpase-Activating Protein 7Start Domain-Containing Protein 12Stard12Star-Related Lipid Transfer Protein 12 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionMembranePeripheral Membrane ProteinColocalizes With Ef1a1 At Actin-Rich Regions In The Cell Periphery |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 7 antibodyAnti-Deleted In Liver Cancer 1 Protein antibodyAnti-Dlc-1 antibodyAnti-Hp Protein antibodyAnti-Rho-Type Gtpase-Activating Protein 7 antibodyAnti-Start Domain-Containing Protein 12 antibodyAnti-Stard12 antibodyAnti-Star-Related Lipid Transfer Protein 12 antibodyAnti-DLC1 antibodyAnti-ARHGAP7 antibodyAnti-KIAA1723 antibodyAnti-STARD12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
