Anti-DLAT antibody (1-290) (STJ28210)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DLAT (1-290) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:20-1:50ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DLAT |
| Gene ID | 1737 |
| Uniprot ID | ODP2_HUMAN |
| Immunogen Region | 1-290 |
| Immunogen Sequence | MWRVCARRAQNVAPWAGLEA RWTALQEVPGTPRVTSRSGP APARRNSVTTGYGGVRALCG WTPSSGATPRNRLLLQLLGS PGRRYYSLPPHQKVPLPSLS PTMQAGTIARWEKKEGDKIN EGDLIAEVETDKATVGFESL EECYMAKILVAEGTRDVPIG AIICITVGKPEDIEAFKNYT LDSSAAPTPQAAPAPTPAAT ASPPTPSAQAPGSSYPPHMQ VLLPALSPTMTMGTVQRWE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human DLAT (NP_001922.2). |
Additional Info
| Post Translational Modifications | Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity. |
| Function | As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety (Probable). The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). |
| Protein Name | Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex - Mitochondrial70 Kda Mitochondrial Autoantigen Of Primary Biliary CirrhosisPbcDihydrolipoamide Acetyltransferase Component Of Pyruvate Dehydrogenase ComplexM2 Antigen Complex 70 Kda SubunitPyruvate Dehydrogenase Complex Component E2Pdc-E2Pdce2 |
| Database Links | Reactome: R-HSA-204174Reactome: R-HSA-5362517Reactome: R-HSA-9857492Reactome: R-HSA-9861559 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex - Mitochondrial antibodyAnti-70 Kda Mitochondrial Autoantigen Of Primary Biliary Cirrhosis antibodyAnti-Pbc antibodyAnti-Dihydrolipoamide Acetyltransferase Component Of Pyruvate Dehydrogenase Complex antibodyAnti-M2 Antigen Complex 70 Kda Subunit antibodyAnti-Pyruvate Dehydrogenase Complex Component E2 antibodyAnti-Pdc-E2 antibodyAnti-Pdce2 antibodyAnti-DLAT antibodyAnti-DLTA antibody |
Information sourced from Uniprot.org