Anti-DKK4 antibody (19-224) (STJ110107)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DKK4 (19-224) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DKK4 |
| Gene ID | 27121 |
| Uniprot ID | DKK4_HUMAN |
| Immunogen Region | 19-224 |
| Immunogen Sequence | LVLDFNNIRSSADLHGARKG SQCLSDTDCNTRKFCLQPRD EKPFCATCRGLRRRCQRDAM CCPGTLCVNDVCTTMEDATP ILERQLDEQDGTHAEGTTGH PVQENQPKRKPSIKKSQGRK GQEGESCLRTFDCGPGLCCA RHFWTKICKPVLLEGQVCSR RGHKDTAQAPEIFQRCDCGP GLLCRSQLTSNRQHARLRVC QKIEKL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 19-224 of human DKK4 (NP_055235.1). |
Additional Info
| Tissue Specificity | Expressed in cerebellum, T-cells, esophagus and lung. |
| Post Translational Modifications | Appears to be not glycosylated. Can be proteolytically processed by a furin-like protease. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 4Dickkopf-4Dkk-4Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 4 antibodyAnti-Dickkopf-4 antibodyAnti-Dkk-4 antibodyAnti-Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form antibodyAnti-DKK4 antibody |
Information sourced from Uniprot.org