Host: |
Goat |
Applications: |
Pep-ELISA/WB |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Goat polyclonal antibody anti-DKK3/REIC (C-Term) is suitable for use in ELISA and Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: |
0.5 mg/mL |
Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:16000. |
Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: |
DKK3 |
Gene ID: |
27122 |
Uniprot ID: |
DKK3_HUMAN |
Immunogen Region: |
C-Term |
Accession Number: |
NP_037385.2; NP_056965.3; NP_001018067.1 |
Specificity: |
NP_037385.2; NP_056965.3 and NP_001018067.1 are varients of the same protein. |
Immunogen Sequence: |
AAAALLGGEEI |
Post Translational Modifications | N- and O-glycosylated. |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
Protein Name | Dickkopf-Related Protein 3Dickkopf-3Dkk-3Hdkk-3 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Dickkopf-Related Protein 3 antibodyAnti-Dickkopf-3 antibodyAnti-Dkk-3 antibodyAnti-Hdkk-3 antibodyAnti-DKK3 antibodyAnti-REIC antibodyAnti-UNQ258 antibodyAnti-PRO295 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance