Anti-DKK3 antibody [SAA1719] (STJA0020147)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Dickkopf-Related Protein 3 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1719 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | DKK3 |
| Gene ID | 27122 |
| Uniprot ID | DKK3_HUMAN |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 3Dickkopf-3Dkk-3Hdkk-3 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 3 antibodyAnti-Dickkopf-3 antibodyAnti-Dkk-3 antibodyAnti-Hdkk-3 antibodyAnti-DKK3 antibodyAnti-REIC antibodyAnti-UNQ258 antibodyAnti-PRO295 antibody |
Information sourced from Uniprot.org