Anti-DKK3 antibody (22-350aa) [AT103B5] (STJA0041849)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human DKK3 (22-350aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-DKK3 (22-350aa) for use in ELISA and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT103B5 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DKK3 |
| Gene ID | 27122 |
| Uniprot ID | DKK3_HUMAN |
| Accession Number | NP_001018067 |
| Immunogen | Recombinant human DKK3 (22-350aa) purified from E. coli |
| Immunogen Region | 22-350aa |
Additional Info
| Tissue Specificity | Highest expression in heart, brain, and spinal cord. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 3Dickkopf-3Dkk-3Hdkk-3 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 3 antibodyAnti-Dickkopf-3 antibodyAnti-Dkk-3 antibodyAnti-Hdkk-3 antibodyAnti-DKK3 antibodyAnti-REIC antibodyAnti-UNQ258 antibodyAnti-PRO295 antibody |
Information sourced from Uniprot.org