| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DKK1 (32-266) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DKK1 |
| Gene ID: |
22943 |
| Uniprot ID: |
DKK1_HUMAN |
| Immunogen Region: |
32-266 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 32-266 of human DKK1 (NP_036374.1). |
| Immunogen Sequence: |
TLNSVLNSNAIKNLPPPLGG AAGHPGSAVSAAPGILYPGG NKYQTIDNYQPYPCAEDEEC GTDEYCASPTRGGDAGVQIC LACRKRRKRCMRHAMCCPGN YCKNGICVSSDQNHFRGEIE ETITESFGNDHSTLDGYSRR TTLSSKMYHTKGQEGSVCLR SSDCASGLCCARHFWSKICK PVLKEGQVCTKHRRKGSHGL EIFQRCYCGEGLSCRIQKDH HQASNSSRLHTCQRH |
| Tissue Specificity | Placenta. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. |
| Protein Name | Dickkopf-Related Protein 1Dickkopf-1Dkk-1Hdkk-1Sk |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 1 antibodyAnti-Dickkopf-1 antibodyAnti-Dkk-1 antibodyAnti-Hdkk-1 antibodyAnti-Sk antibodyAnti-DKK1 antibodyAnti-UNQ492 antibodyAnti-PRO1008 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
