Name: Anti-DKK1 antibody [2H2] (STJ98000)
SKU: STJ98000
Availability: InStock

Anti-DKK1 antibody [2H2] (STJ98000)

SKU:

STJ98000

€178.80 - €432.00

Short Description :	Mouse monoclonal anti-Dickkopf-related protein 1 for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:	WB/ELISA
Host:	Mouse
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality :	Monoclonal
Clone ID :	2H2
Isotype:	IgG2b
Conjugation:	Unconjugated
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 ELISA 1:10000
Formulation:	Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DKK1
Gene ID:	22943
Uniprot ID:	DKK1_HUMAN
Immunogen:	Purified recombinant fragment of Dkk-1 expressed in E. Coli.
Specificity:	Dkk-1 Monoclonal Antibody detects endogenous levels of Dkk-1 protein.

Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
Protein Name	Dickkopf-Related Protein 1 Dickkopf-1 Dkk-1 Hdkk-1 Sk
Database Links	Reactome: R-HSA-201681 Reactome: R-HSA-3772470 Reactome: R-HSA-5339717
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Dickkopf-Related Protein 1 antibody Anti-Dickkopf-1 antibody Anti-Dkk-1 antibody Anti-Hdkk-1 antibody Anti-Sk antibody Anti-DKK1 antibody Anti-UNQ492 antibody Anti-PRO1008 antibody

Information sourced from Uniprot.org

Anti-DKK1 antibody [2H2] (STJ98000)

General Information

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