• Immunofluorescence analysis of HeLa cells, using Dyskerin Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from JurKat cells, using Dyskerin Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of HeLa cells using Dyskerin Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-DKC1 antibody (171-220 aa) (STJ92804)

SKU:
STJ92804

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-H/ACA ribonucleoprotein complex subunit DKC1 (171-220 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DKC1
Gene ID: 1736
Uniprot ID: DKC1_HUMAN
Immunogen Region: 171-220 aa
Specificity: Dyskerin Polyclonal Antibody detects endogenous levels of Dyskerin protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Dyskerin at the amino acid range 171-220
Function Isoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression.
Protein Name H/Aca Ribonucleoprotein Complex Subunit Dkc1
Cbf5 Homolog
Dyskerin
Nopp140-Associated Protein Of 57 Kda
Nucleolar Protein Nap57
Nucleolar Protein Family A Member 4
Snornp Protein Dkc1
Database Links Reactome: R-HSA-171319
Reactome: R-HSA-6790901
Cellular Localisation Isoform 1: Nucleus
Nucleolus
Nucleus
Cajal Body
Also Localized To Cajal Bodies (Coiled Bodies)
Isoform 3: Cytoplasm
Alternative Antibody Names Anti-H/Aca Ribonucleoprotein Complex Subunit Dkc1 antibody
Anti-Cbf5 Homolog antibody
Anti-Dyskerin antibody
Anti-Nopp140-Associated Protein Of 57 Kda antibody
Anti-Nucleolar Protein Nap57 antibody
Anti-Nucleolar Protein Family A Member 4 antibody
Anti-Snornp Protein Dkc1 antibody
Anti-DKC1 antibody
Anti-NOLA4 antibody

Information sourced from Uniprot.org

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