Anti-Dihydrofolate Reductase/DHFR antibody (1-187aa) [AT5B2] (STJA0041751)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human DHFR (1-187aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Dihydrofolate Reductase/DHFR (1-187aa) for use in ELISA and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT5B2 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHFR |
| Gene ID | 1719 |
| Uniprot ID | DYR_HUMAN |
| Accession Number | NP_000782 |
| Immunogen | Recombinant human DHFR (1-187aa) purified from E. coli |
| Immunogen Region | 1-187aa |
Additional Info
| Tissue Specificity | Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. |
| Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. |
| Protein Name | Dihydrofolate Reductase |
| Database Links | Reactome: R-HSA-1474151Reactome: R-HSA-196757Reactome: R-HSA-69205 |
| Cellular Localisation | MitochondrionCytoplasm |
| Alternative Antibody Names | Anti-Dihydrofolate Reductase antibodyAnti-DHFR antibody |
Information sourced from Uniprot.org