| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DIAPH3 (630-849) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DIAPH3 |
| Gene ID: |
81624 |
| Uniprot ID: |
DIAP3_HUMAN |
| Immunogen Region: |
630-849 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 630-849 of human DIAPH3 (NP_112194.2). |
| Immunogen Sequence: |
KYPDILNFVDDLEPLDKASK VSVETLEKNLRQMGRQLQQL EKELETFPPPEDLHDKFVTK MSRFVISAKEQYETLSKLHE NMEKLYQSIIGYYAIDVKKV SVEDFLTDLNNFRTTFMQAI KENIKKREAEEKEKRVRIAK ELAERERLERQQKKKRLLEM KTEGDETGVMDNLLEALQSG AAFRDRRKRTPMPKDVRQSL SPMSQRPVLKVCNHGNKPYL |
| Post Translational Modifications | Ubiquitinated. |
| Function | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. |
| Protein Name | Protein Diaphanous Homolog 3Diaphanous-Related Formin-3Drf3Mdia2 |
| Database Links | Reactome: R-HSA-5663220Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | CytoplasmNucleusDuring MitosisCo-Localizes With The Actin-Rich Cleavage Furrow And With The Microtubule-Rich Central Spindle During CytokinesisShuttles Between The Cytoplasm And The Nucleus |
| Alternative Antibody Names | Anti-Protein Diaphanous Homolog 3 antibodyAnti-Diaphanous-Related Formin-3 antibodyAnti-Drf3 antibodyAnti-Mdia2 antibodyAnti-DIAPH3 antibodyAnti-DIAP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
