Anti-DHX16 antibody (216-266 aa) (STJ194116)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human DHX16 at the amino acid range 216-266
General Information
| Short Description | Rabbit polyclonal anti-Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (216-266 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHX16 |
| Gene ID | 8449 |
| Uniprot ID | DHX16_HUMAN |
| Immunogen | Synthesized peptide derived from the human DHX16 at the amino acid range 216-266 |
| Immunogen Region | 216-266 aa |
| Specificity | This antibody detects endogenous levels of DHX16 at Human |
Additional Info
| Function | Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses. |
| Protein Name | Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16Atp-Dependent Rna Helicase #3Deah-Box Protein 16 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmCytoplasm |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16 antibodyAnti-Atp-Dependent Rna Helicase #3 antibodyAnti-Deah-Box Protein 16 antibodyAnti-DHX16 antibodyAnti-DBP2 antibodyAnti-DDX16 antibodyAnti-KIAA0577 antibodyAnti-PRP2 antibody |
Information sourced from Uniprot.org