Anti-DHX15 antibody (STJA0007463)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DHX15
General Information
| Short Description | Rabbit polyclonal anti-ATP-dependent RNA helicase DHX15 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHX15 |
| Gene ID | 1665 |
| Uniprot ID | DHX15_HUMAN |
| Immunogen | Synthesized peptide derived from human DHX15 |
| Specificity | This antibody detects endogenous levels of DHX15 at Human, Mouse |
Additional Info
| Function | RNA helicase involved in mRNA processing and antiviral innate immunity. Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome. Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses. The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu. Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells. |
| Protein Name | Atp-Dependent Rna Helicase Dhx15Atp-Dependent Rna Helicase #46Deah Box Protein 15Splicing Factor Prp43Hprp43 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Dhx15 antibodyAnti-Atp-Dependent Rna Helicase #46 antibodyAnti-Deah Box Protein 15 antibodyAnti-Splicing Factor Prp43 antibodyAnti-Hprp43 antibodyAnti-DHX15 antibodyAnti-DBP1 antibodyAnti-DDX15 antibody |
Information sourced from Uniprot.org