Anti-DHRS11 antibody (1-260) (STJ116632)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DHRS11 (1-260) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHRS11 |
| Gene ID | 79154 |
| Uniprot ID | DHR11_HUMAN |
| Immunogen Region | 1-260 |
| Immunogen Sequence | MARPGMERWRDRLALVTGAS GGIGAAVARALVQQGLKVVG CARTVGNIEELAAECKSAGY PGTLIPYRCDLSNEEDILSM FSAIRSQHSGVDICINNAGL ARPDTLLSGSTSGWKDMFNV NVLALSICTREAYQSMKERN VDDGHIININSMSGHRVLPL SVTHFYSATKYAVTALTEGL RQELREAQTHIRATCISPGV VETQFAFKLHDKDPEKAAAT YEQMKCLKPEDVAEAVIYV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DHRS11 (NP_077284.2). |
Additional Info
| Tissue Specificity | Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart. Isoform 3: Expressed in brain, heart and skeletal muscle. |
| Function | Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 1117-Beta-Hydroxysteroid Dehydrogenase3-Beta-Hydroxysteroid 3-DehydrogenaseEstradiol 17-Beta-DehydrogenaseShort-Chain Dehydrogenase/Reductase Family 24c Member 1 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 11 antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-3-Beta-Hydroxysteroid 3-Dehydrogenase antibodyAnti-Estradiol 17-Beta-Dehydrogenase antibodyAnti-Short-Chain Dehydrogenase/Reductase Family 24c Member 1 antibodyAnti-DHRS11 antibodyAnti-SDR24C1 antibodyAnti-UNQ836 antibodyAnti-PRO1774 antibody |
Information sourced from Uniprot.org