| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DHCR24 (227-516) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHCR24 |
| Gene ID: |
1718 |
| Uniprot ID: |
DHC24_HUMAN |
| Immunogen Region: |
227-516 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577.1). |
| Immunogen Sequence: |
AEIRIIPAKKYVKLRFEPVR GLEAICAKFTHESQRQENHF VEGLLYSLDEAVIMTGVMTD EAEPSKLNSIGNYYKPWFFK HVENYLKTNREGLEYIPLRH YYHRHTRSIFWELQDIIPFG NNPIFRYLFGWMVPPKISLL KLTQGETLRKLYEQHHVVQD MLVPMKCLQQALHTFQNDIH VYPIWLCPFILPSQPGLVHP KGNEAELYIDIGAYGEPRVK HFEARSCMRQLEKFVRSVH |
| Tissue Specificity | Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. |
| Function | Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. |
| Protein Name | Delta(24-Sterol Reductase24-Dehydrocholesterol Reductase3-Beta-Hydroxysterol Delta-24-ReductaseDiminuto/Dwarf1 HomologSeladin-1 |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-6807047Reactome: R-HSA-6807062 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Delta(24-Sterol Reductase antibodyAnti-24-Dehydrocholesterol Reductase antibodyAnti-3-Beta-Hydroxysterol Delta-24-Reductase antibodyAnti-Diminuto/Dwarf1 Homolog antibodyAnti-Seladin-1 antibodyAnti-DHCR24 antibodyAnti-KIAA0018 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
