| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Diacylglycerol kinase alpha (304-353 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DGKA |
| Gene ID: | 1606 |
| Uniprot ID: | DGKA_HUMAN |
| Immunogen Region: | 304-353 aa |
| Specificity: | DGK-Alpha Polyclonal Antibody detects endogenous levels of DGK-Alpha protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human DGKA at the amino acid range 304-353 |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol. |
| Protein Name | Diacylglycerol Kinase Alpha Dag Kinase Alpha 80 Kda Diacylglycerol Kinase Diglyceride Kinase Alpha Dgk-Alpha |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Alpha antibody Anti-Dag Kinase Alpha antibody Anti-80 Kda Diacylglycerol Kinase antibody Anti-Diglyceride Kinase Alpha antibody Anti-Dgk-Alpha antibody Anti-DGKA antibody Anti-DAGK antibody Anti-DAGK1 antibody |
Information sourced from Uniprot.org