Anti-DET1 antibody (15-240) (STJ112015)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DET1 (15-240) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DET1 |
| Gene ID | 55070 |
| Uniprot ID | DET1_HUMAN |
| Immunogen Region | 15-240 |
| Immunogen Sequence | HVSTIKPRRIQNQNVIHRLE RRRISSGKAGTHWHQVRVFH QNVFPNFTVVNVEKPPCFLR KFSPDGRYFIAFSSDQTSLE IYEYQGCQAAEDLLQGYEGE ILSNGNDQRSVNIRGRLFER FFVLLHITNVAANGEHLNRE CSLFTDDCRCVIVGSAAYLP DEPHPPFFEVYRNSESVTPN PRSPLEDYSLHIIDLHTGRL CDTRTFKCDKVVLSHNQGLY LYKNIL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 15-240 of human DET1 (NP_060466.2). |
Additional Info
| Tissue Specificity | Highly expressed in the ovary, some lymphoid organs and resting leukocytes. |
| Function | Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. |
| Protein Name | Det1 HomologDe-Etiolated-1 Homolog |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Det1 Homolog antibodyAnti-De-Etiolated-1 Homolog antibodyAnti-DET1 antibody |
Information sourced from Uniprot.org