Anti-Desmocollin 3 antibody [R06-4G2] (STJA0033826)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Desmocollin 3
General Information
| Short Description | Rabbit monoclonal anti-Desmocollin 3 for use in WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-4G2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DSC3 |
| Gene ID | 1825 |
| Uniprot ID | DSC3_HUMAN |
| Immunogen | A synthetic peptide of human Desmocollin 3 |
Additional Info
| Tissue Specificity | Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level). Also expressed in the buccal mucosa, esophagus and cervix (at protein level). |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function. Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage. Essential for successful completion of embryo compaction and embryo development. |
| Protein Name | Desmocollin-3Cadherin Family Member 3Desmocollin-4Ht-Cp |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosomeCytoplasmExpressed In The Cytoplasm And At The Cell Membrane Of Oocytes |
| Alternative Antibody Names | Anti-Desmocollin-3 antibodyAnti-Cadherin Family Member 3 antibodyAnti-Desmocollin-4 antibodyAnti-Ht-Cp antibodyAnti-DSC3 antibodyAnti-CDHF3 antibodyAnti-DSC4 antibody |
Information sourced from Uniprot.org