Anti-DEPTOR antibody (87-137) (STJA0006635)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DPTOR AA range: 87-137
General Information
| Short Description | Rabbit polyclonal anti-DEP domain-containing mTOR-interacting protein (87-137) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DEPTOR |
| Gene ID | 64798 |
| Uniprot ID | DPTOR_HUMAN |
| Immunogen | Synthesized peptide derived from human DPTOR AA range: 87-137 |
| Immunogen Region | 87-137 |
| Specificity | This antibody detects endogenous levels of human DPTOR |
Additional Info
| Function | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity. |
| Protein Name | Dep Domain-Containing Mtor-Interacting ProteinHdeptorDep Domain-Containing Protein 6 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneLocalizes To The Lysosomal Membrane When Associated With The Mtorc1 And Mtorc2 Complexes |
| Alternative Antibody Names | Anti-Dep Domain-Containing Mtor-Interacting Protein antibodyAnti-Hdeptor antibodyAnti-Dep Domain-Containing Protein 6 antibodyAnti-DEPTOR antibodyAnti-DEPDC6 antibody |
Information sourced from Uniprot.org