| Tissue Specificity | Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney. |
| Function | Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. |
| Protein Name | Density-Regulated ProteinDrpProtein Drp1Smooth Muscle Cell-Associated Protein 3Smap-3 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Density-Regulated Protein antibodyAnti-Drp antibodyAnti-Protein Drp1 antibodyAnti-Smooth Muscle Cell-Associated Protein 3 antibodyAnti-Smap-3 antibodyAnti-DENR antibodyAnti-DRP1 antibodyAnti-H14 antibody |
Information sourced from Uniprot.org
