Anti-DENND1A antibody (14-64 aa) (STJ195500)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human DEN1A at the amino acid range 14-64
General Information
| Short Description | Rabbit polyclonal anti-DENN domain-containing protein 1A (14-64 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DENND1A |
| Gene ID | 57706 |
| Uniprot ID | DEN1A_HUMAN |
| Immunogen | Synthesized peptide derived from the human DEN1A at the amino acid range 14-64 |
| Immunogen Region | 14-64 aa |
| Specificity | This antibody detects endogenous levels of DEN1A at Human/Mouse |
Additional Info
| Function | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P. |
| Protein Name | Denn Domain-Containing Protein 1aConnecdenn 1ConnecdennProtein Fam31a |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinPresynaptic Cell MembraneAssociates To Membranes Via Lipid-Binding Activity |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 1a antibodyAnti-Connecdenn 1 antibodyAnti-Connecdenn antibodyAnti-Protein Fam31a antibodyAnti-DENND1A antibodyAnti-FAM31A antibodyAnti-KIAA1608 antibody |
Information sourced from Uniprot.org