| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DEGS1 (234-323) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:3000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEGS1 |
| Gene ID: |
8560 |
| Uniprot ID: |
DEGS1_HUMAN |
| Immunogen Region: |
234-323 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 234-323 of human DEGS1 (NP_003667.1). |
| Immunogen Sequence: |
YMFLKGHETYSYYGPLNLLT FNVGYHNEHHDFPNIPGKSL PLVRKIAAEYYDNLPHYNSW IKVLYDFVMDDTISPYSRMK RHQKGEMVLE |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels. |
| Function | Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols. |
| Protein Name | Sphingolipid Delta(4-Desaturase Des1Cell Migration-Inducing Gene 15 ProteinDegenerative Spermatocyte Homolog 1Dihydroceramide Desaturase-1Membrane Lipid DesaturaseRetinol Isomerase |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-6798695 |
| Cellular Localisation | Mitochondrion MembraneEndoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sphingolipid Delta(4-Desaturase Des1 antibodyAnti-Cell Migration-Inducing Gene 15 Protein antibodyAnti-Degenerative Spermatocyte Homolog 1 antibodyAnti-Dihydroceramide Desaturase-1 antibodyAnti-Membrane Lipid Desaturase antibodyAnti-Retinol Isomerase antibodyAnti-DEGS1 antibodyAnti-DES1 antibodyAnti-MLD antibodyAnti-MIG15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
