Anti-Deformed Epidermal Autoregulatory Factor 1 antibody (500-565) (STJ500747)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 500-565 on mouse Deformed epidermal autoregulatory factor 1 homolog protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-Deformed Epidermal Autoregulatory Factor 1 (500-565) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.5 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150ICC: 1:50-1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Deaf1 |
| Gene ID | 54006 |
| Uniprot ID | DEAF1_MOUSE |
| Immunogen | Synthetic peptide taken within amino acid region 500-565 on mouse Deformed epidermal autoregulatory factor 1 homolog protein. |
| Immunogen Region | 500-565 |
Additional Info
| Tissue Specificity | Ubiquitously expressed during embryogenesis, with higher expression in regions of the central nervous system, dorsal root ganglia, submandibular gland, epidermis and breast. In 12-week-old NOD mice, expression of isoform 2 is sevenfold higher in lymph node stromal elements than in T-cells and tenfold higher than in B-cells. |
| Post Translational Modifications | May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro). |
| Function | Transcription factor that binds to sequence with multiple copies of 5'-TTCCGG-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. May also involved in behavior. |
| Protein Name | Deformed Epidermal Autoregulatory Factor 1 HomologNuclear Deaf-1-Related Transcriptional RegulatorNudr |
| Cellular Localisation | Isoform 1: NucleusCytoplasmIsoform 2: CytoplasmNucleusDisplays Some Nuclear Localization When Expressed With Isoform 1Suggesting That It May Heterodimerize With Isoform 1 And Shuttle To The Nucleus Using The Nuclear Localization Signal Of Isoform 1 |
| Alternative Antibody Names | Anti-Deformed Epidermal Autoregulatory Factor 1 Homolog antibodyAnti-Nuclear Deaf-1-Related Transcriptional Regulator antibodyAnti-Nudr antibodyAnti-Deaf1 antibody |
Information sourced from Uniprot.org