| Host: |
Rabbit |
| Applications: |
IHC/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Defensin beta 4A (1-50 aa) is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200ELISA-Pep 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEFB4A.DEFB4B |
| Gene ID: |
100289462/1673 |
| Uniprot ID: |
DFB4A_HUMAN |
| Immunogen Region: |
1-50 aa |
| Specificity: |
This antibody detects endogenous levels of human Beta-defensin 4A |
| Immunogen: |
Synthesized peptide derived from the human Beta-defensin 4A at the amino acid range 1-50 |
| Function | Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells. |
| Protein Name | Defensin Beta 4aBeta-Defensin 2Bd-2Hbd-2Defensin - Beta 2Skin-Antimicrobial Peptide 1Sap1 |
| Database Links | Reactome: R-HSA-1461957Reactome: R-HSA-1461973 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Defensin Beta 4a antibodyAnti-Beta-Defensin 2 antibodyAnti-Bd-2 antibodyAnti-Hbd-2 antibodyAnti-Defensin - Beta 2 antibodyAnti-Skin-Antimicrobial Peptide 1 antibodyAnti-Sap1 antibodyAnti-DEFB4A antibodyAnti-DEFB102 antibodyAnti-DEFB2 antibodyAnti-DEFB4.DEFB4B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
