| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DEFB4A (1-64) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEFB4A.DEFB4B |
| Gene ID: |
100289462/1673 |
| Uniprot ID: |
DFB4A_HUMAN |
| Immunogen Region: |
1-64 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-64 of human DEFB4A (NP_004933.1). |
| Immunogen Sequence: |
MRVLYLLFSFLFIFLMPLPG VFGGIGDPVTCLKSGAICHP VFCPRRYKQIGTCGLPGTKC CKKP |
| Tissue Specificity | Expressed in lung epithelial cells (at protein level). Expressed in foreskin, lung and trachea. Lower expression in kidney, uterus and salivary gland tissue. Expressed in epithelial cells of the respiratory tract, with higher expression in distal parenchyma of the lung, trachea, and tonsils, and lower expression in pharynx and adenoid, and low expression in tongue and larynx. |
| Function | Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells. |
| Protein Name | Defensin Beta 4aBeta-Defensin 2Bd-2Hbd-2Defensin - Beta 2Skin-Antimicrobial Peptide 1Sap1 |
| Database Links | Reactome: R-HSA-1461957Reactome: R-HSA-1461973 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Defensin Beta 4a antibodyAnti-Beta-Defensin 2 antibodyAnti-Bd-2 antibodyAnti-Hbd-2 antibodyAnti-Defensin - Beta 2 antibodyAnti-Skin-Antimicrobial Peptide 1 antibodyAnti-Sap1 antibodyAnti-DEFB4A antibodyAnti-DEFB102 antibodyAnti-DEFB2 antibodyAnti-DEFB4.DEFB4B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
