Anti-DEFA4 antibody (27-76 aa) (STJ92689)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Defensin alpha4 at the amino acid range 27-76
General Information
| Short Description | Rabbit polyclonal anti-Defensin alpha 4 (27-76 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DEFA4 |
| Gene ID | 1669 |
| Uniprot ID | DEF4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Defensin alpha4 at the amino acid range 27-76 |
| Immunogen Region | 27-76 aa |
| Specificity | Defensin Alpha 4 Polyclonal Antibody detects endogenous levels of Defensin Alpha 4 protein. |
Additional Info
| Post Translational Modifications | The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for effective bacterial killing. |
| Function | Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef. Protects blood cells against infection with HIV-1 (in vitro). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro). |
| Protein Name | Defensin Alpha 4Corticostatin Hp-4Hnp-4Hp-4Neutrophil Defensin 4 |
| Database Links | Reactome: R-HSA-1461973Reactome: R-HSA-1462054Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedCytoplasmic VesicleSecretory VesicleStored As Mature Peptide In Neutrophil Granules |
| Alternative Antibody Names | Anti-Defensin Alpha 4 antibodyAnti-Corticostatin Hp-4 antibodyAnti-Hnp-4 antibodyAnti-Hp-4 antibodyAnti-Neutrophil Defensin 4 antibodyAnti-DEFA4 antibodyAnti-DEF4 antibody |
Information sourced from Uniprot.org