Anti-Dectin-1 antibody (66-247 aa) [SRM5408] (STJ11107319)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Dectin-1 (66-247 aa) antibody for use in IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5408 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Target Information
| Gene Symbol | CLEC7A |
| Gene ID | 64581 |
| Uniprot ID | CLC7A_HUMAN |
| Immunogen Region | 66-247 aa |
| Immunogen Sequence | TMAIWRSNSGSNTLENGYFL SRNKENHSQPTQSSLEDSVT PTKAVKTTGVLSSPCPPNWI IYEKSCYLFSMSLNSWDGSK RQCWQLGSNLLKIDSSNELG FIVKQVSSQPDNSFWIGLSR PQTEVPWLWEDGSTFSSNLF QIRTTATQENPSPNCVWIHV SVIYDQLCSVPSYSICEKKF SM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 66-247 of human Dectin-1 (NP_922938.1). |
Additional Info
| Tissue Specificity | Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to beta-glucan binding. |
| Function | Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
| Protein Name | C-Type Lectin Domain Family 7 Member ABeta-Glucan ReceptorC-Type Lectin Superfamily Member 12Dendritic Cell-Associated C-Type Lectin 1Dc-Associated C-Type Lectin 1Dectin-1Cd Antigen Cd369 |
| Database Links | Reactome: R-HSA-5607764 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 5: CytoplasmIsoform 6: CytoplasmIsoform 7: Cytoplasm |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 7 Member A antibodyAnti-Beta-Glucan Receptor antibodyAnti-C-Type Lectin Superfamily Member 12 antibodyAnti-Dendritic Cell-Associated C-Type Lectin 1 antibodyAnti-Dc-Associated C-Type Lectin 1 antibodyAnti-Dectin-1 antibodyAnti-Cd Antigen Cd369 antibodyAnti-CLEC7A antibodyAnti-BGR antibodyAnti-CLECSF12 antibodyAnti-DECTIN1 antibodyAnti-UNQ539 antibodyAnti-PRO1082 antibody |
Information sourced from Uniprot.org