Anti-DDX6 antibody (101-200) [S2MR] (STJ11102512)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal DDX6 (101-200) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DDX6 |
| Gene ID | 1656 |
| Uniprot ID | DDX6_HUMAN |
| Immunogen Region | 101-200 |
| Immunogen Sequence | YCLKRELLMGIFEMGWEKPS PIQEESIPIALSGRDILARA KNGTGKSGAYLIPLLERLDL KKDNIQAMVIVPTRELALQV SQICIQVSKHMGGAKVMATT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 101-200 of human DDX6 (P26196). |
Additional Info
| Tissue Specificity | Abundantly expressed in most tissues. |
| Post Translational Modifications | Sumoylated. |
| Function | Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx6Atp-Dependent Rna Helicase P54Dead Box Protein 6Oncogene Rck |
| Database Links | Reactome: R-HSA-430039 |
| Cellular Localisation | CytoplasmP-BodyNucleusCytoplasmic Ribonucleoprotein GranuleImported In The Nucleus Via Interaction With Eif4enif1/4e-T Via A Piggy-Back MechanismUpon Cellular StressRelocalizes To Stress Granules |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx6 antibodyAnti-Atp-Dependent Rna Helicase P54 antibodyAnti-Dead Box Protein 6 antibodyAnti-Oncogene Rck antibodyAnti-DDX6 antibodyAnti-HLR2 antibodyAnti-RCK antibody |
Information sourced from Uniprot.org