| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP-dependent RNA helicase DDX42 (850-930 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DDX42 |
| Gene ID: |
11325 |
| Uniprot ID: |
DDX42_HUMAN |
| Immunogen Region: |
850-930 aa |
| Specificity: |
DDX42 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 850-930 |
| Function | ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. |
| Protein Name | Atp-Dependent Rna Helicase Ddx42Dead Box Protein 42Rna Helicase-Like ProteinRhelpRna Helicase-Related ProteinRnahpSf3b Dead Box ProteinSplicing Factor 3b-Associated 125 Kda ProteinSf3b125 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | CytoplasmNucleusIsoform 2: NucleusCajal BodyNucleus Speckle |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Ddx42 antibodyAnti-Dead Box Protein 42 antibodyAnti-Rna Helicase-Like Protein antibodyAnti-Rhelp antibodyAnti-Rna Helicase-Related Protein antibodyAnti-Rnahp antibodyAnti-Sf3b Dead Box Protein antibodyAnti-Splicing Factor 3b-Associated 125 Kda Protein antibodyAnti-Sf3b125 antibodyAnti-DDX42 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
