Anti-DDX4/Vasa antibody [SAA1970] (STJA0020398)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Probable Atp-Dependent Rna Helicase Ddx4 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1970 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | DDX4 |
| Gene ID | 54514 |
| Uniprot ID | DDX4_HUMAN |
Additional Info
| Function | ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx4Dead Box Protein 4Vasa Homolog |
| Database Links | Reactome: R-HSA-5601884Reactome: R-HSA-9696264 |
| Cellular Localisation | CytoplasmPerinuclear RegionComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx4 antibodyAnti-Dead Box Protein 4 antibodyAnti-Vasa Homolog antibodyAnti-DDX4 antibodyAnti-VASA antibody |
Information sourced from Uniprot.org