| Tissue Specificity | Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine. |
| Post Translational Modifications | Ubiquitinated by MDM2 without targeting DDX24 for proteasomal degradation. Instead, polyubiquitinated DDX24 promotes interaction with NIP7, a component of pre-rRNP processing complex, and associates with pre-rRNA molecules and pre-ribosomal particles. |
| Function | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA. (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles. |
| Protein Name | Atp-Dependent Rna Helicase Ddx24Dead Box Protein 24 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Ddx24 antibodyAnti-Dead Box Protein 24 antibodyAnti-DDX24 antibody |
Information sourced from Uniprot.org
