| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein Ddi1 Homolog 2 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: |
Antigen affinity purification |
| Concentration: |
1.32 mg/mL |
| Dilution Range: |
WB 1:500-1:2000, IHC 1:50-1:300 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: |
DDI2 |
| Gene ID: |
84301 |
| Uniprot ID: |
DDI2_HUMAN |
| Immunogen: |
Fusion protein of human DDI2 |
| Function | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity. |
| Protein Name | Protein Ddi1 Homolog 2 |
| Cellular Localisation | CytoplasmCytosolChromosome |
| Alternative Antibody Names | Anti-Protein Ddi1 Homolog 2 antibodyAnti-DDI2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
