Anti-DDHD2 antibody (STJA0007372)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DDHD2
General Information
| Short Description | Rabbit polyclonal anti-Phospholipase DDHD2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DDHD2 |
| Gene ID | 23259 |
| Uniprot ID | DDHD2_HUMAN |
| Immunogen | Synthesized peptide derived from human DDHD2 |
| Specificity | This antibody detects endogenous levels of DDHD2 at Human, Mouse |
Additional Info
| Function | Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system. It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL. In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. |
| Protein Name | Triacylglycerol Hydrolase Ddhd2Tag HydrolaseDdhd Domain-Containing Protein 2Kiaa0725pPhospholipase Ddhd2Sam - Wwe And Ddhd Domain-Containing Protein 1Triglyceride Hydrolase Ddhd2Triglyceride Lipase |
| Database Links | Reactome: R-HSA-1483166 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum-Golgi Intermediate CompartmentGolgi ApparatusCis-Golgi NetworkCycles Between The Golgi Apparatus And The CytosolDdhd2 Recruitment To The Golgi/Endoplasmic Reticulum-Golgi Intermediate Compartment (Ergic) Is Regulated By The Levels Of PhosphoinositidesIncluding Pi(4)P |
| Alternative Antibody Names | Anti-Triacylglycerol Hydrolase Ddhd2 antibodyAnti-Tag Hydrolase antibodyAnti-Ddhd Domain-Containing Protein 2 antibodyAnti-Kiaa0725p antibodyAnti-Phospholipase Ddhd2 antibodyAnti-Sam - Wwe And Ddhd Domain-Containing Protein 1 antibodyAnti-Triglyceride Hydrolase Ddhd2 antibodyAnti-Triglyceride Lipase antibodyAnti-DDHD2 antibodyAnti-KIAA0725 antibodyAnti-SAMWD1 antibody |
Information sourced from Uniprot.org