Anti-DDAH2 antibody (179-229) (STJA0006507)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DDAH2 AA range: 179-229
General Information
| Short Description | Rabbit polyclonal anti-NG, NG-dimethylarginine dimethylaminohydrolase 2 (179-229) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DDAH2 |
| Gene ID | 23564 |
| Uniprot ID | DDAH2_HUMAN |
| Immunogen | Synthesized peptide derived from human DDAH2 AA range: 179-229 |
| Immunogen Region | 179-229 |
| Specificity | This antibody detects endogenous levels of human DDAH2 |
Additional Info
| Post Translational Modifications | Phosphorylated by TBK1. Phosphorylation inhibits the translocation into the mitochondrion upon Sendai viral infection. |
| Function | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS. In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase. Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein. Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS. |
| Protein Name | Putative Hydrolase Ddah2DdahiiInactive N(G -N(G-Dimethylarginine Dimethylaminohydrolase 2Ddah-2Inactive Dimethylarginine Dimethylaminohydrolase 2Protein G6aS-Phase Protein |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrionTranslocates From Cytosol To Mitochondrion Upon Il1b Stimulation In Chondrocytes(Microbial Infection) Translocates To The Mitochondrion Upon Sendai Viral Infection |
| Alternative Antibody Names | Anti-Putative Hydrolase Ddah2 antibodyAnti-Ddahii antibodyAnti-Inactive N(G -N(G-Dimethylarginine Dimethylaminohydrolase 2 antibodyAnti-Ddah-2 antibodyAnti-Inactive Dimethylarginine Dimethylaminohydrolase 2 antibodyAnti-Protein G6a antibodyAnti-S-Phase Protein antibodyAnti-DDAH2 antibodyAnti-DDAH antibodyAnti-G6A antibodyAnti-NG30 antibody |
Information sourced from Uniprot.org