Anti-DCUN1D5 antibody (STJA0007796)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DCUN1D5
General Information
| Short Description | Rabbit polyclonal anti-DCN1-like protein 5 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCUN1D5 |
| Gene ID | 84259 |
| Uniprot ID | DCNL5_HUMAN |
| Immunogen | Synthesized peptide derived from human DCUN1D5 |
| Specificity | This antibody detects endogenous levels of DCUN1D5 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-41 is independent of cullin's interaction. Phosphorylated in response to both TICAM1 and MYD88 dependent Toll-like receptor (TLR) pathway activation. Phosphorylated in response to IL1B stimulation. |
| Function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth. |
| Protein Name | Dcn1-Like Protein 5Dcnl5Dcun1 Domain-Containing Protein 5Defective In Cullin Neddylation Protein 1-Like Protein 5Squamous Cell Carcinoma-Related Oncogene 5 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleSubcellular Localization Is Independent Of The Interaction With Cullins |
| Alternative Antibody Names | Anti-Dcn1-Like Protein 5 antibodyAnti-Dcnl5 antibodyAnti-Dcun1 Domain-Containing Protein 5 antibodyAnti-Defective In Cullin Neddylation Protein 1-Like Protein 5 antibodyAnti-Squamous Cell Carcinoma-Related Oncogene 5 antibodyAnti-DCUN1D5 antibodyAnti-SCCRO5 antibody |
Information sourced from Uniprot.org