Anti-DCUN1D1 antibody (STJA0007942)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DCUN1D1
General Information
| Short Description | Rabbit polyclonal anti-DCN1-like protein 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCUN1D1 |
| Gene ID | 54165 |
| Uniprot ID | DCNL1_HUMAN |
| Immunogen | Synthesized peptide derived from human DCUN1D1 |
| Specificity | This antibody detects endogenous levels of DCUN1D1 at Human, Mouse |
Additional Info
| Post Translational Modifications | Mono- and poly-ubiquitinated by ARIH2 and ARIH1. Monoubiquitination by ARIH2 is mediated by an interaction between autoubiquitinated ARIH2 and the UBA-like domain. The monoubiquitinated form preferentially interacts with non-neddylated cullins and modulates cullin RING ligase (CRL) complex composition and activity. |
| Function | Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Also acts as an oncogene facilitating malignant transformation and carcinogenic progression. |
| Protein Name | Dcn1-Like Protein 1Dcnl1Dcun1 Domain-Containing Protein 1Defective In Cullin Neddylation Protein 1-Like Protein 1Squamous Cell Carcinoma-Related Oncogene |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasmThe Ubiquitinated Form Is Localized In The Cytoplasm |
| Alternative Antibody Names | Anti-Dcn1-Like Protein 1 antibodyAnti-Dcnl1 antibodyAnti-Dcun1 Domain-Containing Protein 1 antibodyAnti-Defective In Cullin Neddylation Protein 1-Like Protein 1 antibodyAnti-Squamous Cell Carcinoma-Related Oncogene antibodyAnti-DCUN1D1 antibodyAnti-DCN1 antibodyAnti-DCUN1L1 antibodyAnti-RP42 antibodyAnti-SCCRO antibody |
Information sourced from Uniprot.org