| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DCTN2 |
| Gene ID: | 10540 |
| Uniprot ID: | DCTN2_HUMAN |
| Immunogen Region: | 280-401 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-401 of human DCTN2 (NP_006391.1). |
| Immunogen Sequence: | VLDQVEARLQSVLGKVNEIA KHKASVEDADTQSKVHQLYE TIQRWSPIASTLPELVQRLV TIKQLHEQAMQFGQLLTHLD TTQQMIANSLKDNTTLLTQV QTTMRENLATVEGNFASIDE RM |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. |
| Protein Name | Dynactin Subunit 250 Kda Dynein-Associated PolypeptideDynactin Complex 50 Kda SubunitDctn-50P50 Dynamitin |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-2565942Reactome: R-HSA-3371497Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Dynactin Subunit 2 antibodyAnti-50 Kda Dynein-Associated Polypeptide antibodyAnti-Dynactin Complex 50 Kda Subunit antibodyAnti-Dctn-50 antibodyAnti-P50 Dynamitin antibodyAnti-DCTN2 antibodyAnti-DCTN50 antibody |
Information sourced from Uniprot.org
