| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DCT |
| Gene ID: | 1638 |
| Uniprot ID: | TYRP2_HUMAN |
| Immunogen Region: | 50-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human DCT (NP_001913.2). |
| Immunogen Sequence: | NVCGSQQGRGQCTEVRADTR PWSGPYILRNQDDRELWPRK FFHRTCKCTGNFAGYNCGDC KFGWTGPNCERKKPPVIRQN IHSLSPQEREQFLGALDLAK KRVHPDYVITTQHWLGLLGP NGTQPQFANCSVYDFFVWLH YYSVRDTLLGPGRPYRAIDF SHQGPAFVTWHRYHLLCLER DLQRLIGNESFALPYWNFAT GRNECDVCTDQLFGAARPDD PTLISRNSRFSSWETVCDS |
| Post Translational Modifications | Glycosylated. |
| Function | Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). |
| Protein Name | L-Dopachrome TautomeraseDctDtL-Dopachrome Delta-IsomeraseTyrosinase-Related Protein 2Trp-2Trp2 |
| Database Links | Reactome: R-HSA-5662702Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinMelanosomeProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-L-Dopachrome Tautomerase antibodyAnti-Dct antibodyAnti-Dt antibodyAnti-L-Dopachrome Delta-Isomerase antibodyAnti-Tyrosinase-Related Protein 2 antibodyAnti-Trp-2 antibodyAnti-Trp2 antibodyAnti-DCT antibodyAnti-TYRP2 antibody |
Information sourced from Uniprot.org