Anti-DCSTAMP antibody [SAA1901] (STJA0020329)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Dendritic Cell-Specific Transmembrane Protein antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1901 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | DCSTAMP |
| Gene ID | 81501 |
| Uniprot ID | DCSTP_HUMAN |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. |
| Protein Name | Dendritic Cell-Specific Transmembrane ProteinDc-StampHdc-StampDendrocyte-Expressed Seven Transmembrane ProteinIl-Four-Induced ProteinFindTransmembrane 7 Superfamily Member 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneEndosomeLocalizes To The Cell Surface In Osteoclasts And Undifferentiated MonocytesIntracellular Internalized Dcstamp Is Detected In A Fraction Of Rankl-Induced Osteoclast PrecursorColocalizes With Os9 In The Endoplasmic Reticulum (Er) Of Immature Dendritic Cell (Dc)Translocates From The Endoplasmic Reticulum To The Intermediate/Golgi Compartment Upon Maturation Of Dc In A Os9-Dependent MannerColocalizes With Lamp1 In Endosomes |
| Alternative Antibody Names | Anti-Dendritic Cell-Specific Transmembrane Protein antibodyAnti-Dc-Stamp antibodyAnti-Hdc-Stamp antibodyAnti-Dendrocyte-Expressed Seven Transmembrane Protein antibodyAnti-Il-Four-Induced Protein antibodyAnti-Find antibodyAnti-Transmembrane 7 Superfamily Member 4 antibodyAnti-DCSTAMP antibodyAnti-TM7SF4 antibody |
Information sourced from Uniprot.org