| Tissue Specificity | Detected in liver, brain, kidney, testis and prostate. |
| Function | Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway.m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. |
| Protein Name | M7gpppx DiphosphataseDcs-1Decapping Scavenger EnzymeHint-Related 7megmp-Directed HydrolaseHistidine Triad Nucleotide-Binding Protein 5Histidine Triad Protein Member 5Hint-5Scavenger Mrna-Decapping Enzyme Dcps |
| Database Links | Reactome: R-HSA-429958 |
| Cellular Localisation | CytoplasmNucleusPredominantly Localized In The NucleusNucleocytoplasmic Shuttling Protein That Can Transiently Enter The Cytoplasm In Mammalian Cells In A Xpo1/Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-M7gpppx Diphosphatase antibodyAnti-Dcs-1 antibodyAnti-Decapping Scavenger Enzyme antibodyAnti-Hint-Related 7megmp-Directed Hydrolase antibodyAnti-Histidine Triad Nucleotide-Binding Protein 5 antibodyAnti-Histidine Triad Protein Member 5 antibodyAnti-Hint-5 antibodyAnti-Scavenger Mrna-Decapping Enzyme Dcps antibodyAnti-DCPS antibodyAnti-DCS1 antibodyAnti-HINT5 antibodyAnti-HSPC015 antibody |
Information sourced from Uniprot.org
