Anti-DCC antibody (441-490 aa) (STJ92665)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DCC at the amino acid range 441-490
General Information
| Short Description | Rabbit polyclonal anti-Netrin receptor DCC (441-490 aa) for use in WB, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCC |
| Gene ID | 1630 |
| Uniprot ID | DCC_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DCC at the amino acid range 441-490 |
| Immunogen Region | 441-490 aa |
| Specificity | DCC Polyclonal Antibody detects endogenous levels of DCC protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. |
| Protein Name | Netrin Receptor DccColorectal Cancer SuppressorImmunoglobulin Superfamily Dcc Subclass Member 1Tumor Suppressor Protein Dcc |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376172Reactome: R-HSA-418885Reactome: R-HSA-418886Reactome: R-HSA-418889Reactome: R-HSA-418890Reactome: R-HSA-428542 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Netrin Receptor Dcc antibodyAnti-Colorectal Cancer Suppressor antibodyAnti-Immunoglobulin Superfamily Dcc Subclass Member 1 antibodyAnti-Tumor Suppressor Protein Dcc antibodyAnti-DCC antibodyAnti-IGDCC1 antibody |
Information sourced from Uniprot.org