Anti-DC-SIGNR/CD299 antibody [SRM13269] (STJ11107999)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal C-Type Lectin Domain Family 4 Member M antibody for use in WB, IF, ICC, FC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/FC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM13269 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB, 1:1000-1:5000IF/ICC, 1:50-1:200FC, 1:500-1:1000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC4M |
| Gene ID | 10332 |
| Uniprot ID | CLC4M_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Immunogen Sequence | Human |
Additional Info
| Function | Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. (Microbial infection) Acts as an attachment receptor for HIV-1. (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. (Microbial infection) Acts as an attachment receptor for Influenzavirus. (Microbial infection) Acts as an attachment receptor for SARS-CoV. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. |
| Protein Name | C-Type Lectin Domain Family 4 Member MCd209 Antigen-Like Protein 1Dc-Sign-Related ProteinDc-SignrDendritic Cell-Specific Icam-3-Grabbing Non-Integrin 2Dc-Sign2Liver/Lymph Node-Specific Icam-3-Grabbing Non-IntegrinL-SignCd Antigen Cd299 |
| Database Links | Reactome: R-HSA-9833110 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 2: Cell MembraneIsoform 3: Cell MembraneIsoform 5: SecretedIsoform 6: SecretedIsoform 7: SecretedIsoform 10: Secreted |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member M antibodyAnti-Cd209 Antigen-Like Protein 1 antibodyAnti-Dc-Sign-Related Protein antibodyAnti-Dc-Signr antibodyAnti-Dendritic Cell-Specific Icam-3-Grabbing Non-Integrin 2 antibodyAnti-Dc-Sign2 antibodyAnti-Liver/Lymph Node-Specific Icam-3-Grabbing Non-Integrin antibodyAnti-L-Sign antibodyAnti-Cd Antigen Cd299 antibodyAnti-CLEC4M antibodyAnti-CD209L antibodyAnti-CD209L1 antibodyAnti-CD299 antibody |
Information sourced from Uniprot.org