| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DBNL (131-430) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DBNL |
| Gene ID: |
28988 |
| Uniprot ID: |
DBNL_HUMAN |
| Immunogen Region: |
131-430 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 131-430 of human DBNL (NP_001014436.1). |
| Immunogen Sequence: |
KVAKASGANYSFHKESGRFQ DVGPQAPVGSVYQKTNAVSE IKRVGKDSFWAKAEKEEENR RLEEKRRAEEAQRQLEQERR ERELREAARREQRYQEQGGE ASPQRTWEQQQEVVSRNRNE QESAVHPREIFKQKERAMST TSISSPQPGKLRSPFLQKQL TQPETHFGREPAAAISRPRA DLPAEEPAPSTPPCLVQAEE EAVYEEPPEQETFYEQPPLV QQQGAGSEHIDHHIQGQGL |
| Post Translational Modifications | Degraded by caspases during apoptosis. |
| Function | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. |
| Protein Name | Drebrin-Like ProteinCervical Sh3p7Cervical Mucin-Associated ProteinDrebrin-FHpk1-Interacting Protein Of 55 KdaHip-55Sh3 Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6794361Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumRuffleCell CortexCytosolSynapsePerikaryonNeuron ProjectionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleClathrin-Coated Vesicle MembraneGolgi Apparatus MembranePodosomeEarly EndosomeDendritePostsynaptic DensityAssociates With Lamellipodial Actin And Membrane RufflesColocalizes With Actin And Cortactin At Podosome Dots And Podosome Rosettes |
| Alternative Antibody Names | Anti-Drebrin-Like Protein antibodyAnti-Cervical Sh3p7 antibodyAnti-Cervical Mucin-Associated Protein antibodyAnti-Drebrin-F antibodyAnti-Hpk1-Interacting Protein Of 55 Kda antibodyAnti-Hip-55 antibodyAnti-Sh3 Domain-Containing Protein 7 antibodyAnti-DBNL antibodyAnti-CMAP antibodyAnti-SH3P7 antibodyAnti-PP5423 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
