| Short Description : | Rabbit polyclonal DBI (1-104) antibody for use in WB, IP and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DBI |
| Gene ID: | 1622 |
| Uniprot ID: | ACBP_HUMAN |
| Immunogen Region: | 1-104 |
| Immunogen Sequence: | MWGDLWLLPPASANPGTGTE AEFEKAAEEVRHLKTKPSDE EMLFIYGHYKQATVGDINTE RPGMLDFTGKAKWDAWNELK GTSKEDAMKAYINKVEELKK KYGI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-104 of human DBI (NP_001171513.1). |
| Tissue Specificity | Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. |
| Function | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. |
| Protein Name | Acyl-Coa-Binding ProteinAcbpDiazepam-Binding InhibitorDbiEndozepineEp |
| Database Links | Reactome: R-HSA-77289 |
| Cellular Localisation | Endoplasmic ReticulumGolgi ApparatusGolgi Localization Is Dependent On Ligand Binding |
| Alternative Antibody Names | Anti-Acyl-Coa-Binding Protein antibodyAnti-Acbp antibodyAnti-Diazepam-Binding Inhibitor antibodyAnti-Dbi antibodyAnti-Endozepine antibodyAnti-Ep antibodyAnti-DBI antibody |
Information sourced from Uniprot.org
