| Tissue Specificity | Highly expressed in testis and thymus. Expressed also in most cancer cells lines. |
| Post Translational Modifications | Phosphorylation increases its interaction with PSIP1. |
| Function | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. |
| Protein Name | Protein Dbf4 Homolog AActivator Of S Phase KinaseChiffon Homolog ADbf4-Type Zinc Finger-Containing Protein 1 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-68962 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Dbf4 Homolog A antibodyAnti-Activator Of S Phase Kinase antibodyAnti-Chiffon Homolog A antibodyAnti-Dbf4-Type Zinc Finger-Containing Protein 1 antibodyAnti-DBF4 antibodyAnti-ASK antibodyAnti-DBF4A antibodyAnti-ZDBF1 antibody |
Information sourced from Uniprot.org
