Anti-DAPK2 antibody (300-350) {Biotin} (STJ500730)

SKU:
STJ500730-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DAPK2 (300-350) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Dapk2
Gene ID: 13143
Uniprot ID: DAPK2_MOUSE
Immunogen Region: 300-350
Immunogen: Synthetic peptide take within amino acid region 300-350 on mouse Death-associated protein kinase 2 protein.
Tissue Specificity Expressed in peritubular interstitial cells of the renal cortex. Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level).
Post Translational Modifications Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.
Function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytes motility by controlling cell spreading and polarization.
Protein Name Death-Associated Protein Kinase 2
Dap Kinase 2
Dap-Kinase-Related Protein 1
Drp-1
Cellular Localisation Cytoplasm
Cytoplasmic Vesicle
Autophagosome Lumen
Alternative Antibody Names Anti-Death-Associated Protein Kinase 2 antibody
Anti-Dap Kinase 2 antibody
Anti-Dap-Kinase-Related Protein 1 antibody
Anti-Drp-1 antibody
Anti-Dapk2 antibody

Information sourced from Uniprot.org

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