Anti-DAND5 antibody (STJA0008829)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DAND5
General Information
| Short Description | Rabbit polyclonal anti-DAN domain family member 5 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DAND5 |
| Gene ID | 199699 |
| Uniprot ID | DAND5_HUMAN |
| Immunogen | Synthesized peptide derived from human DAND5 |
| Specificity | This antibody detects endogenous levels of DAND5 at Human, Mouse |
Additional Info
| Function | Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development. Antagonist of BMP and TGF-beta signaling. Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway. Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance. |
| Protein Name | Dan Domain Family Member 5Cerberus-Like Protein 2Cerl-2Cysteine Knot Superfamily 1 - Bmp Antagonist 3Gremlin-3 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617 |
| Cellular Localisation | SecretedCirculating Dand5 May Be Uptaken By Endothelial Cells And Transported To Mitochondria |
| Alternative Antibody Names | Anti-Dan Domain Family Member 5 antibodyAnti-Cerberus-Like Protein 2 antibodyAnti-Cerl-2 antibodyAnti-Cysteine Knot Superfamily 1 - Bmp Antagonist 3 antibodyAnti-Gremlin-3 antibodyAnti-DAND5 antibodyAnti-CER2 antibodyAnti-CKTSF1B3 antibodyAnti-COCO antibodyAnti-GREM3 antibodyAnti-SP1 antibody |
Information sourced from Uniprot.org