| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-DAGLA (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.3-1µg/mlIHC-5µg/mlELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
DAGLA |
| Gene ID: |
747 |
| Uniprot ID: |
DGLA_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_006124.1 |
| Immunogen Sequence: |
PAKQDELVISAR |
| Post Translational Modifications | Phosphorylated at Ser-782 and Ser-808 by CAMK2A.phosphorylation by CAMK2A inhibits diacylglycerol lipase activity. |
| Function | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation. |
| Protein Name | Diacylglycerol Lipase-AlphaDagl-AlphaDgl-AlphaNeural Stem Cell-Derived Dendrite RegulatorSn1-Specific Diacylglycerol Lipase Alpha |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Density MembraneEarly Endosome MembraneCell ProjectionDendritic Spine MembraneCycles Between The Cell Surface And An Intracellular Endosomal CompartmentInternalized By Early Endosomes Via A Clathrin-Independent Pathway Before Transport Back To The Postsynaptic Membrane Surface In A Pkc-Dependent Manner |
| Alternative Antibody Names | Anti-Diacylglycerol Lipase-Alpha antibodyAnti-Dagl-Alpha antibodyAnti-Dgl-Alpha antibodyAnti-Neural Stem Cell-Derived Dendrite Regulator antibodyAnti-Sn1-Specific Diacylglycerol Lipase Alpha antibodyAnti-DAGLA antibodyAnti-C11orf11 antibodyAnti-KIAA0659 antibodyAnti-NSDDR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
