Anti-DAAM1 antibody (400-500 aa) (STJ98677)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the human protein at the amino acid range 400-500
General Information
| Short Description | Rabbit polyclonal anti-Disheveled-associated activator of morphogenesis 1 (400-500 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DAAM1 |
| Gene ID | 23002 |
| Uniprot ID | DAAM1_HUMAN |
| Immunogen | Synthetic peptide from the human protein at the amino acid range 400-500 |
| Immunogen Region | 400-500 aa |
| Specificity | The antibody detects endogenous DAAM1 |
Additional Info
| Function | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Together with DAAM2, required for myocardial maturation and sarcomere assembly. During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. |
| Protein Name | Disheveled-Associated Activator Of Morphogenesis 1 |
| Database Links | Reactome: R-HSA-4086400Reactome: R-HSA-5663220Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyPerinuclearColocalizes With Rhoa And Kank1 Around Centrosomes |
| Alternative Antibody Names | Anti-Disheveled-Associated Activator Of Morphogenesis 1 antibodyAnti-DAAM1 antibodyAnti-KIAA0666 antibody |
Information sourced from Uniprot.org